Thermo Fisher Scientific ABHD3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite unrelated sequences and different substrates, they share the canonical α/β hydrolase fold—an eight-stranded parallel α/β structure—and a catalytic triad composed of histidine, acid, and nucleophile.
Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.
The ABHD gene subfamily includes 15 mostly uncharacterized members, most utilizing a serine nucleophile forming the G-X-S-X-G nucleophile elbow.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Involved in atherosclerosis development
• ABHD3: 409 amino acid single-pass type II membrane protein
• ABHD4: Participates in N-acyl ethanolamine (NAE) synthesis pathway
• ABHD5: Mutations linked to Chanarin-Dorfman syndrome
• ABDH6: May play a role in nervous system metabolism and signaling

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.