Thermo Fisher Scientific Caspase 8 (Cleaved Asp384) Polyclonal Antibody
Caspase 8 단백질의 Asp384 절단 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 및 Rat 반응성, 액상 형태로 1 mg/mL 농도 제공. 세포 사멸 연구 및 신경퇴행 질환 연구에 활용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP8 (Accession Q14790), corresponding to amino acid residues K367–P394. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818368 |
Product Specific Information
This antibody detects endogenous levels of the activated Caspase 8 fragment resulting from cleavage adjacent to Asp384.
Target Information
Caspase 8 (CASP8) is a cysteine-aspartic acid protease involved in the execution phase of apoptosis. It exists as an inactive proenzyme that becomes activated through proteolytic cleavage, forming a heterodimeric enzyme composed of large and small subunits. Caspase 8 mediates programmed cell death induced by Fas and other apoptotic stimuli, interacting with FADD via its death effector domain (DED). It has been implicated in neurodegenerative diseases such as Huntington’s disease. Activated Caspase 8 triggers downstream caspases, including Caspase 9, committing the cell to apoptosis. Overexpression induces apoptosis, which can be inhibited by ICE family-specific inhibitors. Multiple alternatively spliced isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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