Thermo Fisher Scientific p70 S6 Kinase Polyclonal Antibody
Rabbit polyclonal antibody targeting human p70 S6 kinase for WB, ICC/IF, and IP applications. Recognizes residues near the carboxy-terminus. Unconjugated liquid form, stored at -20°C. Suitable for research use in studies of cell proliferation and signa...
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Thermo Fisher Scientific p70 S6 Kinase Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding the carboxy-terminus of human p70 S6 kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10988541 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates multiple residues of the S6 ribosomal protein. It is predominantly localized in the cytoplasm and plays a critical role in growth factor-regulated cell proliferation, cell motility, immune response, and tissue repair. Acting downstream of phosphoinositide (PI) 3-kinase, p70 S6 kinase’s main physiological target is the S6 ribosomal protein, which is involved in upregulating protein synthesis. Its kinase activity promotes protein synthesis and cell proliferation. Amplification and overexpression of p70 S6 kinase are observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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