Thermo Fisher Scientific JNK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human JNK1 (MAPK8). Validated for Western blot and ChIP applications. Reacts with multiple species including human, mouse, and rat. Purified by antigen affinity chromatography and supplied in liquid form for researc...
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Thermo Fisher Scientific JNK1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| ChIP assay (ChIP) | 1–3 µL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Hamster, Human, Mouse, Non-human primate, Rat, Yeast, Zebrafish |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant human JNK2 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982589 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is a crucial mediator of insulin resistance and obesity and belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are serine-threonine protein kinases that are activated in response to extracellular stimuli, mediating signal transduction from the cell surface to the nucleus.
JNK participates in various cellular processes including proliferation, differentiation, transcription regulation, and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing, with JNK1 and JNK2 being the predominant forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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