Thermo Fisher Scientific Phospho-Dystroglycan (Tyr892) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated Dystroglycan (Tyr892). Suitable for WB and IHC (Paraffin). Supplied as liquid, 1 mg/mL concentration. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DAG1 around the phosphorylation site of Tyr892. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903169 |
Target Information
Dystroglycan is a laminin-binding component of the dystrophin-glycoprotein complex, providing a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for mutations causing autosomal recessive muscular dystrophies. The reduction of dystroglycan 1 in Duchenne muscular dystrophy disrupts the sarcolemma–extracellular matrix linkage, increasing muscle fiber susceptibility to necrosis. Dystroglycan also functions as a dual receptor for agrin and laminin-2 in Schwann cell membranes. Muscle and nonmuscle isoforms differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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