Thermo Fisher Scientific Phospho-BRCA1 (Ser1497) Polyclonal Antibody
BRCA1 단백질의 Ser1497 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합하며, 인간·마우스·랫트 반응성. 고순도 정제, PBS/glycerol 저장, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCA1 (Accession P38398), corresponding to amino acid residues around phosphorylated Ser1497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903166 |
Product Specific Information
Antibody detects endogenous levels of BRCA1 only when phosphorylated at Ser1497.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that maintains genomic stability and acts as a tumor suppressor. It forms part of the BASC complex with other tumor suppressors and DNA damage sensors. BRCA1 interacts with RNA polymerase II and histone deacetylase complex, playing key roles in transcription, DNA repair, and recombination. Mutations in BRCA1 are responsible for a significant proportion of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, and a related pseudogene is found on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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