Thermo Fisher Scientific KSHV ORF62 Monoclonal Antibody (5B7B6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (IHC)

1:200-1:1,000

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Virus

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

5B7B6

Immunogen

Purified recombinant fragment of human KSHV ORF62 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_10984866

Product Specific Information

MA5-14770 targets KSHV ORF62 in indirect ELISA, IHC and WB applications and shows reactivity with Virus samples.

The MA5-14770 immunogen is purified recombinant fragment of human KSHV ORF62 expressed in E. Coli.

Target Information

Kaposis sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposis sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman`s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.