Thermo Fisher Scientific IL2RB Monoclonal Antibody (OTI1B5), TrueMAB
인간 IL2RB 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot에 적합합니다. TrueMAB 형식으로 고순도 정제되어 있으며, PBS/BSA/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능하며 안정적인 신호 검출을 제공합니다.
- 카탈로그번호
- TA812261
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Human recombinant protein fragment (amino acids 27–240) + Mouse FC of human IL2RB produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three forms:
- Low affinity form: alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: alpha/beta heterodimer
- High affinity form: alpha/beta/gamma heterotrimer
Both intermediate and high affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction. The CD122 gene encodes the beta subunit, a type I membrane protein. Dysfunction of CD122 is associated with diseases such as oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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