Thermo Fisher Scientific C10orf54 Monoclonal Antibody (OTI1D10C1), TrueMAB
Human C10orf54(VISTA) 단백질을 인식하는 mouse monoclonal antibody. Western blot에 최적화되어 있으며, 1:500 희석 권장. Affinity chromatography로 정제된 액상 제품으로, PBS/BSA/glycerol buffer에 보존. 암 면역치료 연구용으로 적합.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D10C1 |
| Immunogen | Full length human recombinant protein of human C10ORF54 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern.
In both mouse and human, VISTA is predominantly expressed on hematopoietic cells—highest on myeloid cells and lower on T cells—and is typically absent on B cells.
VISTA expressed by antigen-presenting cells can suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a valuable target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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