Thermo Fisher Scientific IL2RB Monoclonal Antibody (OTI1D12), TrueMAB
인간 IL2RB(CD122)를 인식하는 Mouse monoclonal antibody입니다. Western blot에 최적화되어 있으며, 고순도의 affinity chromatography로 정제되었습니다. PBS/BSA/glycerol buffer에 보관되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 27–240 + Mouse FC of human IL2RB produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and exists in three forms.
- Low affinity form: Monomer of the alpha subunit, not involved in signal transduction
- Intermediate affinity form: Alpha/beta subunit heterodimer
- High affinity form: Alpha/beta/gamma subunit heterotrimer
Both intermediate and high affinity forms are involved in receptor-mediated endocytosis and mitogenic signal transduction.
The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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