Thermo Fisher Scientific PIK3R6 Polyclonal Antibody
PIK3R6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 적합합니다. 인간, 마우스, 랫트에서 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human PIK3R6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553956 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of approximately 84 kDa.
Purity is >95% by SDS-PAGE.
Target Information
p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84, or HsT41028, is a 754-amino-acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex.
It is expressed in heart, dendritic cells, macrophages, and neutrophils. p87PIKAP drives PI 3-kinase p110 activation, interacts with PDE3B, and promotes scaffolding interactions between the two proteins.
The PIK3R6 gene maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes.
Chromosome 17 includes key tumor suppressor genes such as p53 and BRCA1, both critical for maintaining genomic integrity and DNA repair.
Mutations in BRCA1 are associated with early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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