Thermo Fisher Scientific Phospho-Tau (Thr181) Recombinant Superclonal Antibody (5HCLC)
Phospho-Tau (Thr181) 인산화 타우 단백질을 특이적으로 인식하는 재조합 Superclonal 항체. 인간, 마우스, 랫트 시료에 반응하며 WB 및 IHC(P) 실험에 적합. 폴리클로날의 민감도와 모노클로날의 특이성을 결합한 고재현성 항체.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 5HCLC |
| Immunogen | Human Tau around phosphorylated Tyrosine 181 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532739 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies.
These antibodies provide consistent performance across lots by eliminating biological variability.
Formerly known as “Recombinant Polyclonal Antibody,” this product is now branded as Recombinant Superclonal™ Antibody, with no change in physical product or performance.
Target Information
Tau is a neuronal microtubule-associated protein primarily located on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Hyper-phosphorylated Tau constitutes paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease and other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
Phosphorylation is mediated by several kinases including GSK-3β, PKA, cdk5, and casein kinase II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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