Thermo Fisher Scientific Phospho-Tau (Thr181) Recombinant Superclonal Antibody (5HCLC)

Applications

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies.
These antibodies provide consistent performance across lots by eliminating biological variability.
Formerly known as “Recombinant Polyclonal Antibody,” this product is now branded as Recombinant Superclonal™ Antibody, with no change in physical product or performance.

Target Information

Tau is a neuronal microtubule-associated protein primarily located on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Hyper-phosphorylated Tau constitutes paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease and other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
Phosphorylation is mediated by several kinases including GSK-3β, PKA, cdk5, and casein kinase II.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.