Thermo Fisher Scientific Complement C4b/C4c Polyclonal Antibody, FITC

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Flow Cytometry (Flow)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

C4c complement isolated from complement activated human serum. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Complement C4b/C4c,uniProtId:P0C0L5-1,ncbiNodeId:9606,antigenRange:1-1744,antigenLength:1744,antigenImageFileName:PA1-28407_Complement_C4bC4c_P0C0L5-1_Rabbit.svg,antigenImageFileNamePDP:PA1-28407_Complement_C4bC4c_P0C0L5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

Conc. Not Determined

Purification

IgG fraction

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1956460

Product Specific Information

PA1-28407 detects C4c / C4b from human samples.

Antigen retrieval for IHC (P): Proteinase K 30 min at 37ºC

Target Information

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.