Thermo Fisher Scientific PAG1 Monoclonal Antibody (MEM-255)
인간 PAG1(Cbp) 단백질의 세포질 도메인 내 에피토프를 인식하는 Mouse IgG2a 단클론 항체. Western blot, IHC, Flow cytometry에 사용 가능. 인간 특이적 반응성을 가지며 다른 종과 교차 반응 없음. 단백질 A 정제, 1 mg/mL 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-255 |
| Immunogen | Recombinant intracellular fragment (aa 97–432) of human Cbp (PAG) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2160069 |
Product Specific Information
This antibody recognizes an epitope (aa 235–280) of Csk-binding protein (Cbp) located in the cytoplasmic domain, also known as protein associated with glycosphingolipid-enriched microdomains (PAG).
This antibody does not cross-react with mouse, rat, or bovine.
Target Information
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein localized in membrane rafts (glycosphingolipid-enriched microdomains). It migrates anomalously as an 80 kDa molecule on SDS-PAGE.
Upon tyrosine phosphorylation by Src family kinases, PAG binds and activates Csk, the major negative regulator of Src kinases. In B cells and mast cells, receptor signaling increases PAG phosphorylation and Csk binding, whereas T cell receptor signaling leads to PAG dephosphorylation, loss of Csk binding, and enhanced Lck activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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