Thermo Fisher Scientific Phospho-Connexin 43 (Ser368) Polyclonal Antibody
Phospho-Connexin 43 (Ser368) Rabbit Polyclonal Antibody로, 인간·마우스·랫트 시료에 반응합니다. Western blot, IHC, ICC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포막 및 세포접합부에서 Connexin 43 인산화 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of human Connexin 43 with phosphorylated Ser368 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
Product Specific Information
- Positive control: Human cardiac muscle
- Cellular location: Cell membrane, Cell junction
Target Information
Connexin 43 (Cx43) belongs to the gap junction protein family. Connexins assemble as hexamers forming hemichannels that connect adjacent cells, enabling intercellular communication. Phosphorylation of Cx43, particularly at Ser368 by protein kinase C (PKC), regulates the assembly and function of gap junctions by decreasing cell-to-cell communication.
Cx43 is the predominant gap junction protein in cardiac tissue, playing a crucial role in synchronized heart contraction and embryonic development. It is also regulated by various kinases affecting myocardial cell coupling. A related pseudogene, GJA1P, is located on chromosome 5.
Mutations in related genes can lead to disorders such as Charcot-Marie-Tooth disease, oculodentodigital dysplasia, and heart malformations.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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