Thermo Fisher Scientific Rab5 Polyclonal Antibody
Rab5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Bovine, Human, Mouse, Rat 등 다양한 종에 반응합니다. KLH에 결합된 합성 펩타이드로 면역화되었으며, 단백질 A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human Rab5 synthetic peptide (identical to canine Rab5) conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RAB5 belongs to the small GTPase Rab family, which are key regulators of intracellular membrane trafficking, from vesicle formation to membrane fusion. Rabs cycle between inactive GDP-bound and active GTP-bound forms, recruiting specific downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A is essential for the fusion of plasma membranes and early endosomes, contributes to filopodia extension regulation, and is required for exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also regulates the maturation of apoptotic cell-containing phagosomes, likely downstream of DYN2 and PIK3C3.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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