Thermo Fisher Scientific Human ESX1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the amino terminus of human ESX1.
PEP-1010 can be used as a blocking peptide with polyclonal antibody PA5-20896.

Target Information

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain.
During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion, and the labyrinthine trophoblast of the chorioallantoic placenta.
ESX1 can act as a transcriptional repressor to the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.