Thermo Fisher Scientific Human ESX1 Synthetic Peptide
Human ESX1 단백질의 아미노 말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 폴리클로날 항체 PA5-20896의 블로킹 펩타이드로 사용 가능합니다. 인간 종 특이적이며 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP1010
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human ESX1.
PEP-1010 can be used as a blocking peptide with polyclonal antibody PA5-20896.
Target Information
Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain.
During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion, and the labyrinthine trophoblast of the chorioallantoic placenta.
ESX1 can act as a transcriptional repressor to the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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