Thermo Fisher Scientific CamK4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:15,000

Immunoprecipitation (IP)

• Tested Dilution: 3–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is involved in transcriptional regulation in lymphocytes, neurons, and male germ cells. The nuclear localization of this protein supports its role in calcium-dependent gene expression.
CaMKIV is abundant in testis, T-cells, and neurons, and also present in other tissues to varying degrees. In neurons, it contributes to synaptic plasticity through gene regulation. In T-cells, it plays a role in calcium signaling affecting NFAT activation.
CaMKIV and calspermin are encoded by the CaMKIV gene. In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.