Thermo Fisher Scientific 4-aminobiphenyl DNA Monoclonal Antibody (4C11)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:50-1:100

-

Immunocytochemistry (ICC/IF)

1:50-1:100

-

ELISA (ELISA)

1:100-1:2,000

-

Product Specifications

Species Reactivity

Chemical

Host/Isotype

Mouse

Class

Monoclonal

Type

Antibody

Clone

4C11

Immunogen

4-amino biphenyl DNA.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_568421

Target Information

4-aminoBiphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation. 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.