Thermo Fisher Scientific RPE65 Monoclonal Antibody (401.8B11.3D9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 2 publications 2 publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:500

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

1:250

-

Immunocytochemistry (ICC/IF)

1:50-1:200

View 7 publications 7 publications

Flow Cytometry (Flow)

Assay-Dependent

-

Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Human, Mouse, Non-human primate, Pig, Rat, Xenopus

Published species

Dog, Human, Mouse, Rabbit, Rat, Xenopus

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

401.8B11.3D9

Immunogen

Bovine RPE65 microsomal membrane proteins. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RPE65,uniProtId:Q28175-1,ncbiNodeId:9913,antigenRange:1-533,antigenLength:533,antigenImageFileName:MA1-16578_RPE65_Q28175-1_House_mouse.svg,antigenImageFileNamePDP:MA1-16578_RPE65_Q28175-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• Biotin
• DyLight 488
• DyLight 550
• DyLight 650
• HRP
• Request custom conjugation

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2181003

Target Information

RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.