Thermo Fisher Scientific IL-17F Monoclonal Antibody (SHLR17), PE, eBioscience
인간 IL-17F를 인식하는 SHLR17 단클론 항체로, PE 형광 표지되어 Flow Cytometry용으로 최적화됨. Th17 세포 내 염색에 적합하며, 488–561 nm 레이저에서 검출 가능. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific IL-17F Monoclonal Antibody (SHLR17), PE, eBioscience™
Applications
- Intracellular staining followed by flow cytometric analysis
Tested Dilution
- 5 µL (0.5 µg)/test
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SHLR17 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572654 |
Available Formats
- Brilliant UV 395
- Brilliant UV 563
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 650
- eFluor 450
- eFluor 660
- Functional Grade
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17(A), B, C, D, and E (IL-25).
IL-17A and IL-17F are preferentially produced by Th17 cells, with overlapping yet distinct functions.
IL-17F binds to a heterodimer of IL-17RA and IL-17RC, inducing secretion of pro-inflammatory cytokines and chemokines, and promoting neutrophil recruitment.
Applications Reported:
This antibody is suitable for intracellular staining followed by flow cytometric analysis.
Applications Tested:
Pre-titrated and validated for intracellular staining of TH17-polarized normal human peripheral blood cells.
Use at 5 µL (0.5 µg) per test (100 µL final volume). Cell count: 10⁵–10⁸ cells/test.
Excitation / Emission / Laser:
488–561 nm excitation; 578 nm emission; compatible with Blue, Green, Yellow-Green lasers.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
IL-17F (Interleukin 17F, CTLA-8) is a cytokine of the IL-17 family produced by activated T cells, mast cells, and basophils.
It is involved in allergic airway inflammation and induces cytokines, chemokines, and adhesion molecules in various cell types.
IL-17F acts via the IL-17R receptor, enhancing chemokine production and recruiting monocytes and neutrophils.
It also promotes TNFα, IL-1β, IL-6, and IL-8 production, contributing to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
TGF-β and IL-23 are required for Th17 cell differentiation and maintenance.
IL-17F exists as a homodimer and inhibits angiogenesis while inducing IL-2, TGFB1, and MCP-1 production in endothelial cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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