Thermo Fisher Scientific CDC6 Monoclonal Antibody (OTI1B3), TrueMAB
CDC6 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 인간 유래 단백질을 항원으로 제작되었으며, Lyophilized 형태로 제공됩니다. 연구용으로 DNA 복제 관련 단백질 분석에 활용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B3 |
| Immunogen | Full length human recombinant protein of human CDC6 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CDC6 protein is homologous to Saccharomyces cerevisiae Cdc6, essential for initiating DNA replication. It acts as a regulator during early replication steps, localizing in the nucleus during G1 phase and translocating to the cytoplasm at S phase onset. This translocation is controlled by phosphorylation via Cdks. Transcription of CDC6 is regulated by mitogenic signals through E2F-mediated transcriptional control.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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