Thermo Fisher Scientific uPAR Recombinant Rabbit Monoclonal Antibody (HL2398)
Human uPAR을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체(HL2398). WB 및 IHC(P)에서 사용 가능하며 HEK293 세포에서 발현된 IgG 형식. Protein A로 정제된 액상 형태로, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2398 |
| Immunogen | Recombinant fragment of human uPAR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093134 |
Target Information
The urokinase-type plasminogen activator receptor (uPAR) regulates cell-surface plasminogen activation and plays an important role in normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) in monocytes, anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) interacts with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared to normal tissue. UPAR protein expression correlates positively with recurrence and mortality rates in endometrial cancer patients.
UPAR is considered a useful prognostic marker for advanced endometrial cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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