Thermo Fisher Scientific BRCA1 Polyclonal Antibody
BRCA1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합. 사람, 생쥐, 랫트 반응성. 액상 형태로 1 mg/mL 농도, -20°C 보관. 유전자 안정성 및 암 억제 관련 연구용.
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- PA599524
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Thermo Fisher Scientific BRCA1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCA1 (Accession P38398), corresponding to amino acid residues R1397–Q1447 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818457 |
Product Specific Information
Antibody detects endogenous levels of total BRCA1.
Target Information
BRCA1 (Breast and Ovarian Cancer Susceptibility Protein 1) is a nuclear phosphoprotein that plays a key role in maintaining genomic stability and acts as a tumor suppressor. It forms a large multi-subunit complex known as BASC (BRCA1-associated genome surveillance complex) with other tumor suppressors and DNA damage sensors.
BRCA1 associates with RNA polymerase II and interacts with histone deacetylase complexes, contributing to transcription regulation, DNA repair of double-stranded breaks, and recombination.
Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, with several disease-associated variants identified. A related pseudogene exists on chromosome 17.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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