Thermo Fisher Scientific MAPT Monoclonal Antibody (OTI13B5), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.

• The C-terminus binds axonal microtubules, and the N-terminus binds neural plasma membrane components, functioning as a linker protein.
• Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body.
• Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize the cytoskeleton.
• Hyper-phosphorylated Tau forms paired helical filaments (PHF), a major component of neurofibrillary lesions in Alzheimer’s disease (AD).
• Hyper-phosphorylation disrupts microtubule binding, leading to destabilization and neuronal degeneration.
• Kinases including GSK-3β, PKA, cdk5, and casein kinase II phosphorylate Tau.
• Hyper-phosphorylated Tau is also found in other neurodegenerative diseases such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.