Thermo Fisher Scientific CD184 (CXCR4) Monoclonal Antibody (2B11), PerCP-eFluor 710, eBioscience
Mouse 및 Human CXCR4(CD184)을 인식하는 2B11 클론의 Rat 모노클로날 항체로, PerCP-eFluor 710 형광체로 결합됨. Flow cytometry 분석에 적합하며 HIV-1 coreceptor 연구 및 림프구 이동 관련 연구에 활용 가능. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific CD184 (CXCR4) Monoclonal Antibody (2B11), PerCP-eFluor 710
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1 µg/test
Publications: View 20 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), PerCP-eFluor™ 710 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Conjugate | PerCP-eFluor™ 710 |
| Excitation / Emission Max | 482 / 708 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10670192 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 805
- eFluor 450
- Functional Grade
- PE
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- Super Bright 600
- Custom conjugation available
Product Specific Information
The 2B11 monoclonal antibody reacts with mouse and human CXCR4 (CD184), also known as Fusin, LESTR, or HUMSTR. CXCR4 is a G-protein-coupled chemokine receptor functioning as a coreceptor for X4 HIV-1 entry into CD4+ cells and plays a role in lymphocyte migration. Its ligand is SDF1, essential for granulocyte progenitor maintenance and B cell development.
- Recognizes amino terminus of CXCR4
- Induces receptor internalization without blocking SDF1a
- Tested for flow cytometric analysis of mouse thymocytes
- Recommended ≤1 µg/test (100 µL volume, 10⁵–10⁸ cells/test)
- PerCP-eFluor™ 710 emits at 710 nm, excited by 488 nm blue laser
- Suggested filters: 685 LP dichroic mirror + 710/40 band pass (or 695/40 alternative)
- Stable in 2% formaldehyde fixation at 4°C overnight
- Filtration: 0.2 µm post-manufacturing filtered
Excitation: 488 nm
Emission: 710 nm
Laser: Blue Laser
Target Information
CXCR4 (Fusin, LESTR, HUMSTR) is a seven-transmembrane G-protein-coupled receptor acting as a co-receptor for HIV-1 and HIV-2 entry into CD4+ cells. It binds CXCL12/SDF-1, mediating calcium influx and MAPK activation. CXCR4 is involved in hematopoiesis, cardiac development, vascularization, and CNS neuronal survival. It also mediates LPS-induced inflammatory responses and TNF secretion by monocytes. Antibodies to CXCR4 can block HIV-1/2 fusion and infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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