Thermo Fisher Scientific CD38 Monoclonal Antibody (HB7), PerCP-eFluor 710, eBioscience

Thermo Fisher Scientific CD38 Monoclonal Antibody (HB7), PerCP-eFluor 710, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 6 publications

Product Specifications

Additional Formats

• eFluor 450
• FITC
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 660
• NovaFluor Yellow 755
• PE
• PE-Cyanine7
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 acts as an ectoenzyme catalyzing NAD into NAADP and cyclic ADP-ribose, both secondary messengers. Expression of CD38 varies during B cell development and is also found in T cells, NK cells, monocytes, and various tissues.

Applications Reported: For use in flow cytometric analysis.
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells.
Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, cell number 10⁵–10⁸/test).

PerCP-eFluor® 710 emits at 710 nm and is excited at 488 nm (blue laser). Recommended filter: 710/50 bandpass; alternative: 695/40 bandpass.

Fixation:
Samples can be stored in IC Fixation Buffer (Product # 00-8222-49) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days at 4°C in the dark.

Filtration: 0.2 µm post-manufacturing filtered.

Excitation: 488 nm
Emission: 710 nm
Laser: Blue Laser

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of lymphocytes and apoptosis of progenitor cells. It functions as a multi-catalytic ectoenzyme and surface receptor.
Antibodies to CD38 are useful for subtyping lymphomas and leukemias, detecting plasma cells (myelomas), and identifying activated B and T cells.
CD38 is expressed at high levels in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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