Thermo Fisher Scientific SNX6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Snx6.

Target Information

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal.
Of the type II receptors, SNX6 interacts strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII.
Of the type I receptors, SNX6 interacts only with inactivated TbetaRI.
SNXs 1–4 also interact with the transforming growth factor-beta receptor family, showing different receptor preferences.
Conversely, SNX6 behaves similarly to other SNX proteins in its interactions with receptor tyrosine kinases.
Strong heteromeric interactions are also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes.
These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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