Thermo Fisher Scientific Anoctamin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Anoctamin 2 (TMEM16B). Validated for Western Blot and Immunohistochemistry. Lyophilized form, reconstitutable in sterile water. For research use only, not for diagnostic or resale purposes.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 450–530 of human Anoctamin 1 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Anoctamin 2.
Target Information
Calcium-activated chloride channels (CaCCs) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction.
Subunits of these CaCCs include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues, including olfactory sensory neurons and photoreceptors in the mammalian retina.
Like TMEM16A, TMEM16B is thought to form at least part of CaCCs but has distinct biophysical characteristics such as voltage dependence and unitary conductance.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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