Thermo Fisher Scientific Transglutaminase II (TGM2) (FN Binding Domain) Recombinant Rabbit Monoclonal Antibody (TGM2/6943R)
Recombinant rabbit monoclonal antibody targeting human Transglutaminase II (TGM2). Validated for WB, IHC, ICC/IF, and Flow Cytometry. High specificity and purity (Protein A/G purified). Supplied as liquid form at 1 mg/mL, for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TGM2/6943R |
| Immunogen | Recombinant full-length human TGM2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transglutaminase (TGase) catalyzes protein crosslinking by forming ε-(γ-glutamyl) lysine isopeptide bonds, requiring Ca²⁺ for activity. In mammals, eight TGase isoenzymes are known. Tissue transglutaminase (tTGase or TGase 2) has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains. tTGase is implicated in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity leads to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, forming neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 7052-RBM3-P1ABX_TGM2_P21980-1_Rabbit.svg, 7052-RBM3-P1ABX_TGM2_P21980-1_Rabbit_PDP.jpeg)
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