Thermo Fisher Scientific HSD3B1 Polyclonal Antibody
HSD3B1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. 인체 시료 반응성이 검증되었으며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human HSD3B1 (aa 320–373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913361 |
Product Specific Information
- Positive Control: Human placenta tissue lysates, MCF-7, LOVO, human placenta tissue
- Subcellular Location: Endoplasmic reticulum, Membrane, Mitochondrion
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), which must be activated by the prohormone convertase, furin. The remnant protein is then processed by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, to generate amyloid beta peptide. Gamma-secretase activity is modulated by nicastrin, which binds to the carboxyl-terminus of beta APP. Abeta is found in amyloid cores, neuritic plaques, and neurofibrillary tangles, characteristic of Alzheimer’s disease and other amyloid-related disorders such as Lewy body dementia, Down’s syndrome, and cerebral amyloid angiopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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