Thermo Fisher Scientific ACVR2A Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Positive Control: SW480 cell lysate, K562 cell lysate, HepG2 cell lysate, mouse kidney tissue lysate, mouse testis tissue lysate, rat testis tissue lysate
• Subcellular Location: Membrane

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII)

These receptors are transmembrane proteins composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and expression of type I receptors. After ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered constitutively active kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.