Thermo Fisher Scientific Syk Polyclonal Antibody
Thermo Fisher Scientific의 Syk Polyclonal Antibody는 인간 및 랫트 시료에 반응하며 WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 비결합 항체로, 세포막 및 세포질 내 Syk 단백질 검출에 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human SYK aa 1–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913359 |
Product Specific Information
- Positive Control: Raji cell lysate, Daudi cell lysate, MCF-7, PANC-1, rat kidney tissue, rat heart tissue
- Subcellular Location: Cell membrane, Cytoplasm, Membrane
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for subsequent signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its SH2 domains with ITAM motifs of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-119787_Syk_P43405-1_Rabbit.svg, PA5-119787_Syk_P43405-1_Rabbit_PDP.jpeg)
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