Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody, PeproTech
인간 IL-8(CXCL8)에 특이적인 마우스 단클론 항체로, WB, ELISA 등 다양한 연구 응용에 적합합니다. 고순도 재조합 단백질로 면역화된 후 Protein G로 정제되었습니다. 염증 및 종양 연구에 활용 가능하며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.20–0.40 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| ELISA | 2.0–4.0 µg/mL | View 3 publications |
| Neutralization (Neu) | – | View 2 publications |
| In vitro Assay (IV) | – | View 1 publication |
| Immunostaining (IS) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host/Isotype | Mouse |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | E.coli-derived Recombinant Human IL-8 (CXCL8) (72 a.a.) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
| RRID | AB_3074157 |
Product Specific Information
AA Sequence of recombinant protein:
SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NSPreparation:
Produced in mice immunized with highly pure Recombinant Human IL-8 (CXCL8).
Anti-Human IL-8 (CXCL8)-specific antibody was purified from cell culture by Protein G affinity chromatography.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to IL-8RA and IL-8RB receptors and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression can be induced by diverse inflammatory stimuli in macrophages and endothelial cells, where it is stored in Weibel-Palade bodies.
Initially isolated from osteosarcoma cells, IL-8 contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature includes NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related chemokines form a gene cluster on chromosome 4q.
It plays roles in tumor angiogenesis, growth, and bronchiolitis pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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