Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody, PeproTech

Applications and Tested Dilution

Product Specifications

Product Specific Information

• AA Sequence of recombinant protein:
  SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS

• Preparation:
  Produced in mice immunized with highly pure Recombinant Human IL-8 (CXCL8).
  Anti-Human IL-8 (CXCL8)-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to IL-8RA and IL-8RB receptors and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression can be induced by diverse inflammatory stimuli in macrophages and endothelial cells, where it is stored in Weibel-Palade bodies.
Initially isolated from osteosarcoma cells, IL-8 contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature includes NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related chemokines form a gene cluster on chromosome 4q.
It plays roles in tumor angiogenesis, growth, and bronchiolitis pathogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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