Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/2399)
인간 TIM3/HAVCR2/CD366 단백질을 인식하는 단클론 항체로, Effector T 세포 표지 연구에 적합합니다. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, Protein A/G로 정제된 액상 항체입니다. PBS(pH 7.4)에 보관하며 방부제는 포함되지 않습니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/2399 |
| Immunogen | Recombinant fragment of human TIM3 protein (around aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid Type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and autoimmune disease induction, and it downregulates Th1-mediated immune responses while promoting immune tolerance.
It has pathological relevance in experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where its expression enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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