Thermo Fisher Scientific CDH1 Monoclonal Antibody (OTI1B11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, it is recommended to add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

E-Cadherin (epithelial cadherin) is a calcium-dependent cell-cell adhesion glycoprotein belonging to the cadherin superfamily. It consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic domain.
Mutations in the CDH1 gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression through increased proliferation, invasion, and metastasis.
E-cadherin plays a critical role in maintaining tissue integrity and architecture. In humans, E-cadherin is encoded by the CDH1 gene located on chromosome 16.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.