Thermo Fisher Scientific DRIP5 Polyclonal Antibody
Western blot, IHC, ICC 등 다양한 응용에 적합한 Rabbit polyclonal antibody. Human, Mouse, Rat 반응성. RAP1 유래 합성 펩타이드 면역원 사용. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human RAP1 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, sharing three conserved sequence motifs in common. hRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with an approximate molecular weight of 47 kDa. hRap1 does not interact with TRF1. TRF2, a ubiquitously expressed protein, is implicated in the control of telomere length and contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and localizes to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. Mutant forms of TRF2 have been linked to the prevention of senescence in primary human cells, and inhibition of TRF2 can induce apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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