Thermo Fisher Scientific MMS19 Polyclonal Antibody
MMS19 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Protein A 정제 및 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MMS19 (amino acids 851–950) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4), 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, which mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. Within the CIA complex, MMS19 acts as an adapter between early-acting CIA components and target iron-sulfur proteins such as ERCC2/XPD, FANCJ, and RTEL1, playing a crucial role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. MMS19 also participates in the mitotic spindle-associated MMXD complex, contributing to chromosome segregation by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Additionally, it indirectly acts as a transcriptional coactivator of the estrogen receptor (ER) through its role in iron-sulfur insertion into components of the TFIIH machinery.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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