Thermo Fisher Scientific IRE1a Polyclonal Antibody
IRE1a 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로 다양한 종(Human, Mouse, Pig, Rat)에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 사용 가능하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IRE1a (amino acids 252–260) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4) with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERN1 (endoplasmic reticulum to nucleus signaling 1) encodes a serine/threonine kinase that serves as a sensor of unfolded proteins in the ER. It possesses intrinsic kinase and endoribonuclease activity, playing a key role in transmitting unfolded protein signals from the ER to the nucleus by splicing XBP1 mRNA. ERN1 is critical for fetal viability and cellular response under ER stress conditions. Depletion or inhibition of IRE1 leads to apoptosis under stress conditions that cause unfolded protein accumulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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