Thermo Fisher Scientific ATP Citrate Lyase Polyclonal Antibody
ATP Citrate Lyase 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며, 높은 특이성과 재현성을 제공. 항원 친화 크로마토그래피로 정제되어 95% 이상 순도 보장. 연구용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human ACLY |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2717299 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened for optimal performance.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Purity: >95% by SDS-PAGE.
Target Information
ATP citrate lyase (ACLY) is the key enzyme responsible for cytosolic acetyl-CoA synthesis in many tissues. It functions as a tetramer (~440 kDa) of identical subunits and catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with ATP hydrolysis to ADP and phosphate.
Acetyl-CoA produced by ACLY is essential for lipogenesis and cholesterogenesis. In nervous tissue, ACLY may also contribute to acetylcholine biosynthesis. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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