Thermo Fisher Scientific PGP 9.5 Polyclonal Antibody
PGP 9.5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 신경세포 특이 단백질 연구 및 신경퇴행성 질환 연구에 유용. 동결건조 상태로 제공되며, 재구성 후 안정적 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 50–100 of mouse PGP 9.5 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and human.
- Specificity: PGP 9.5.
Target Information
PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.
This protein is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum. Overexpression is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases. PGP9.5 serves as a useful neuronal marker and is valuable in neurodegenerative disease research, including Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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