Thermo Fisher Scientific PGP 9.5 Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and human.
• Specificity: PGP 9.5.

Target Information

PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.

This protein is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum. Overexpression is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases. PGP9.5 serves as a useful neuronal marker and is valuable in neurodegenerative disease research, including Parkinson’s disease.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.