Thermo Fisher Scientific KAT2B Polyclonal Antibody
PCAF(KAT2B)을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. 합성 펩타이드(aa 400-460)를 면역원으로 제작. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- OSP00170W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 400–460 of human PCAF conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: PCAF.
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It acetylates core histones (H3 and H4) and nucleosome core particles, as well as non-histone proteins such as ACLY, PLK4, and TBX5. PCAF inhibits cell-cycle progression and counteracts the mitogenic activity of adenoviral oncoprotein E1A. It also acts as a circadian transcriptional coactivator enhancing NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 activity. PCAF is involved in heart and limb development by mediating acetylation of TBX5 and regulating its nucleocytoplasmic shuttling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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