Thermo Fisher Scientific Phospho-BCR (Ser301) Polyclonal Antibody
BCR 단백질의 Ser301 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(Paraffin) 분석에 적합. Human, Mouse, Rat, Non-human primate 시료 반응성. 고순도 정제 및 안정한 PBS/glycerol buffer 보존.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCR (Accession P11274), corresponding to amino acid residues around phosphorylated Ser301. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816913 |
Product Specific Information
This antibody detects endogenous levels of Bcr only when phosphorylated at Ser301.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein encoded by sequences from both BCR and ABL, the gene at the chromosome 9 breakpoint.
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The protein exhibits serine/threonine kinase activity and functions as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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