Thermo Fisher Scientific Human FGF-4, Animal-Free Recombinant Protein, PeproTech
Animal-free recombinant human FGF-4 protein for research use. Supports stem cell growth and differentiation studies. High purity (≥95%) and low endotoxin (<0.1 EU/µg). Lyophilized for stable storage at -20°C. Supplied by Thermo Fisher Scientific, Pepro...
- 카탈로그번호
- AF-100-31-xxxxx (3개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human FGF-4, Animal-Free Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to available publications (10)
Miscellaneous PubMed (Misc)
- Refer to available publication (1)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse, Pig |
| Expression System | E. coli |
| Amino acid sequence | GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL |
| Molecular weight | 19.7 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <0.1 EU/µg |
| Activity | Determined by a cell proliferation assay using Balb/c 3T3 cells. Expected ED50 ≤ 10 ng/ml, corresponding to ≥ 1 x 10^5 units/mg |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
- AF-100-31-1MG is provided as 2 × 500 µg (AF-100-31-500UG).
- Recombinant Human FGF-4 is a 19.7 kDa protein consisting of 182 amino acid residues.
- Shipped at ambient temperature.
- For storage, handling, and reconstitution details, refer to the lot-specific Certificate of Analysis.
Target Information
Fibroblast Growth Factor 4 (FGF4) is a member of the FGF family with broad mitogenic and cell survival activities. It plays key roles in stem cell growth and survival during embryogenesis, tissue regeneration, and carcinogenesis.
FGF4 exhibits strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and adult mouse tissues such as testis, intestine, and brain.
Mouse homolog studies suggest roles in bone morphogenesis and limb development via the Sonic Hedgehog (SHH) signaling pathway.
FGF4 also regulates neural progenitor cell proliferation and neuronal differentiation.
Recent studies indicate its growth-promoting role in human embryonic stem cells and a feedback inhibition mechanism through a novel splice isoform that may promote differentiation at later developmental stages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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