Thermo Fisher Scientific TRPV1 Monoclonal Antibody (1F5)
TRPV1 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot 및 ELISA에 적합. 인간과 랫트 시료에 반응하며, GST 태그가 포함된 재조합 단백질로 면역화됨. PBS 용액 형태, 보존제 없음, -20°C에서 보관.
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Thermo Fisher Scientific TRPV1 Monoclonal Antibody (1F5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F5 |
| Immunogen | TRPV1 (NP_542437, 21–124 a.a.) 부분 재조합 단백질, GST 태그 포함 (GST 태그 MW 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CPDPLDGDPN SRPPPAKPQL STAKSRTRLF GKGDSEEAFP VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD SVAASTEKTL RLYDRRSIFE AVAQ
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations (Na⁺, K⁺). Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains.
It is activated by noxious heat and mediates proton influx, possibly contributing to intracellular acidosis in nociceptive neurons. TRPV1 expression is mainly restricted to sensory ganglia neurons.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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