Thermo Fisher Scientific c-Raf Monoclonal Antibody (M208)
c-Raf 단백질을 검출하는 Mouse IgG1 단클론 항체로 Western blot에 적합합니다. Human, Mouse, Rat 시료에 반응하며 Protein G로 정제된 액상 항체입니다. PBS/BSA/glycerol 버퍼에 보관되며 -20°C에서 안정적으로 저장 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific c-Raf Monoclonal Antibody (M208)
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M208 |
| Immunogen | Clone (M208) was generated from a sequence corresponding to amino acids in the N-terminal region of human C-Raf. This sequence shows high homology to rat and mouse C-Raf. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.13 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942712 |
Product Specific Information
This antibody detects a 74 kDa* protein corresponding to the molecular mass of C-Raf on SDS-PAGE immunoblots of human A431 and Jurkat cells.
Target Information
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) that functions downstream of the Ras family of membrane-associated GTPases. Once activated, Raf-1 phosphorylates and activates MEK1 and MEK2, which in turn activate ERK1 and ERK2. Activated ERKs regulate gene expression involved in cell division, apoptosis, differentiation, and migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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