Thermo Fisher Scientific SHP-1 Monoclonal Antibody (M160)
SHP-1 단백질을 특이적으로 인식하는 단클론 항체로, Western blot, ICC/IF, IP에 사용 가능. 인간, 마우스, 랫트 반응성. 단백질 A로 정제된 액상 형태이며, -20°C에서 보관. 연구용으로 세포 신호 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M160 |
| Immunogen | Clone (M160) was generated from a recombinant protein containing amino acids in the C-terminal region of human SHP1. This sequence is highly conserved in rat and mouse SHP1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942715 |
Product Specific Information
This antibody detects a 68 kDa protein in human A431 and Jurkat cells and does not cross-react with SHP2.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a C-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate tyrosine kinase-regulated pathways.
In hematopoietic cells, the N-terminal SH2 domain binds to tyrosine-phosphorylated erythropoietin receptors (EpoR), negatively regulating hematopoietic growth.
Overexpression of SHP-1 in epithelial cells dephosphorylates the Ros receptor tyrosine kinase, reducing Ros-dependent cell proliferation and transformation.
In myeloid cells, SHP-1 associates with the IL-3R beta chain following ligand binding, downregulating IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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