Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
IRE1 alpha 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.02% sodium azide 포함, 냉장 또는 냉동 보관 권장.
- 카탈로그번호
- PA520190
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human IRE1p |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152158 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20190 can be used with blocking peptide PEP-0320
Target Information
ERN1 serine/threonine kinase (endoplasmic reticulum to nucleus signaling 1) is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities and plays a key role in endoplasmic reticulum-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the ER and initiates the unfolded protein response by splicing XBP1 mRNA, converting it into a potent transcriptional activator.
Null mutants are viable but IRE1 is essential under stress conditions that cause unfolded protein accumulation in the ER. Depletion of IRE1p through dominant negative expression leads to apoptosis under such stress conditions.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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