Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
IRE1 alpha 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피로 정제, 인간·마우스·랫트 반응성. 연구용으로 ER 스트레스 및 단백질 접힘 반응 연구에 적합.
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Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.25–0.5 µg/mL | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–20 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human IRE1p |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152827 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20189 can be used with blocking peptide PEP-0319
Target Information
ERN1 (endoplasmic reticulum to nucleus signaling 1) encodes the ER to nucleus signaling protein, a human homologue of the yeast Ire1 gene product.
This protein possesses intrinsic kinase and endoribonuclease activity and plays a key role in ER-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the ER and transmits the unfolded protein signal to the nucleus by splicing XBP1 mRNA, converting it into a potent transcriptional activator.
It is essential for fetal viability and cell survival under stress conditions that cause unfolded protein accumulation in the ER.
Depletion of IRE1p through dominant negative expression leads to apoptosis under such stress conditions.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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