Thermo Fisher Scientific FZD7 Polyclonal Antibody
FZD7 단백질을 인식하는 Goat Polyclonal 항체로, Western Blot과 IHC(Paraffin)에서 사용 가능. 인간 시료에 반응하며, 마우스에서도 예측 반응. 합성 펩타이드 면역원 기반으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RFYHRLSHSSKGET) corresponding to the C-terminus amino acids of FZD7 (aa 559–573) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980704 |
Product Specific Information
- This antibody is predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.
The FZD7 protein includes:
- An N-terminal signal sequence
- 10 cysteine residues typical of the cysteine-rich extracellular domain
- 7 putative transmembrane domains
- An intracellular C-terminal tail with a PDZ domain-binding motif
FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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